夢と希望をもって誰でも斬新な研究ができるよう、この研究室の俗称を“どらえもんラボ”と名付けました。

そして、実験や討論を一緒にやりましょう。

論文報告2024

1. Placement of stent grafts with different calibers into the true and false lumens of anastomotic aneurysms after 

descending aortic replacement for aortic dissection.

Hiroo Uehara, Masateru Uchiyama* and Tomohiro Imazuru

Journal of Cardiothoracic Surgery 2024:19:9

2. Investigating the early diagnosis of pancreatic cancer by surveillance of patients with “K-sign” of the pancreas by 

computed tomography: A prospective study.

Yutaka Takigawa, Junichi Matsui, Takao Igarashi, Masateru Uchiyama, Aya Sasaki

J Hepatobiliary Pancreat Sci. 2024;00:1-10.

3. Graft Protective and Intercellular Immunomodulatory Effects by Adoptive Transfer of an Agonistic Anti-BTLA mAb

(3C10) Induced CD4+CD25+ Regulatory T Cells in Murine Cardiac Allograft Transplant Model.

Hisanori Masaoka, Yasuto Yamamoto, Masateru Uchiyama*, Kazuhito Iguchi, Masahiro Nakamura, Hideo Yagita,

Tomohiro Imazuru, Tomoki Shimokawa.

Transplant Proc. 2024; 56: 692-700.

4. Graft protective effects and donor-specific antibody suppression by CD4+CD25+Foxp3+ regulatory T cell induced

by HMG-CoA reductase inhibitor rosuvastatin in a murine heart transplant model.

Kazuhito Iguchi, Yasuto Yamamoto#, Masateru Uchiyama*, Hisanori Masaoka, Masahiro Nakamura, Hiroyuki 

Shizuka, Tomohiro Imazuru, Tomoki Shimokawa (#; equally contributed author)

Journal of Cardiothoracic Surgery 2024;19:368

論文報告2022

1. Effects of Glycyrrhizic Acid in Licorice on Prolongation of Murine Cardiac Allograft Survival.

Yasuto Yamamoto, Masateru Uchiyama*, Kazuhito Iguchi, Kento Kawai, Tomohiro Imazuru,

Masafumi Kawamura, Tomoki Shimokawa.

Transplant Proc. 2022; 54: 476-481.

2. Evaluation of Cardiac Graft Function by Echocardiography in Mice.

Kazuhito Iguchi, Yasuto Yamamoto, Masateru Uchiyama*, Tsukasa Ikeda, Tomohiro Imazuru, Tomoki Shimokawa.

Transplant Proc. 2022; 54: 492-497.

3. Effects of Each Domain in Recombinant Human Soluble Thrombomodulin on Prolongation of Murine Cardiac

Allograft Survival.

Yasuto Yamamoto, Tsukasa Ikeda, Masateru Uchiyama*, Kazuhito Iguchi, Tomohiro Imazuru,

Tomoki Shimokawa.

Transplant Proc. 2022; 54: 487-491.

4. Saireito (TJ-114) Suppressed Donor-Specific Antibody through Immunomodulatory Effects and Regulatory T

cell Induction in a Murine Heart Transplant Model.

Yasuto Yamamoto, Masateru Uchiyama*, Kento Kawai, Kazuhito Iguchi, Tomohiro Imazuru, Tomoki Shimokawa

Transplant Proc. 2022; 54: 482-486.

5. Successful cases of percutaneous left ventricular assist device “Impella” to fulminant myocarditis

Takayuki Hori, Mitsuru Iida, Masateru Uchiyama, Tomoki Shimokawa

Journal of Cardiothoracic Surgery 2022:17:72

6. Surgical treatment of papillary fibroelastoma of the pulmonary valve: a case report

Hiroo Uehara, Masateru Uchiyama*, Takayuki Hori, Mitsuru Iida, Tomohiro Imazuru, Tomoki Shimokawa

Journal of Cardiothoracic Surgery 2022:17:149

論文報告2021

1. IL‐33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin

transplantation.

Kento Kawai, Masateru Uchiyama, Joanna Hester, Fadi Issa*

American Journal of Transplantation. 2021; 21: 978-92.

2. Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis

In Vivo

George Adigbli, Peng Hua, Masateru Uchiyama, Irene Roberts, Joanna Hester, Suzanne M. Watt and Fadi Issa

Front Immunol. 2021 Mar 25;12:642198.

3. Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation

Keiichi Fujimoto, Koichiro Uchida, Enzhi Yin, Jun Zhu, Yuko Kojima, Masateru Uchiyama, Yasuto Yamamoto,

Hisashi Bashuda, Ryu Matsumoto, Koji Tokushige, Masaki Harada, Takenori Inomata, Jiro Kitaura,

Akira Murakami, Ko Okumura, Kazuyoshi Takeda.

Transpl Immunol. 2021 May 8;67:101405.

4. The “K-Sign”—A Novel CT Finding Suggestive before the Appearance of Pancreatic Cancer.

Yuko Kobashi, Masateru Uchiyama, Junichi Matsui.

Cancers 2021, 13(16), 4222

論文報告2020

1. Surgical Treatment Strategy with Combined Cardiopulmonary Bypass for Renal Cell Carcinoma with Tumor

Embolism Developed in Inferior Vena Cava.

Tomohiro Imazuru*, Masateru Uchiyama, Tomoki Shimokawa.

The Heart Surg Forum. 2020; 23: E025-E029.

2. Our Experience of Surgical Aortic Reconstruction in Patient with Bicuspid Aortic Valve in Japan

Mitsuru Iida*, Masateru Uchiyama, Tsukasa Ikeda, Tomohiro Imazuru, Tomoki Shimokawa.

Journal of Cardiol Ther. 2020; 7: 926-930.

3. Primary malignant pericardial mesothelioma presenting with cardiac tamponade

Shigefumi Matsuyama, Tomohiro Imazuru, Masateru Uchiyama, Hiroo Ota, Mitsuru Iida, Tomoki Shimokawa.

International Journal of Surgery Case Reports. 2020; 73: 253-6.

4. マウストレッドミル運動モデルを用いた芍薬甘草湯による筋肥大抑制効果とCD8陽性細胞の機能抑制効果

山本康人、内山雅照、新見正則

帝京医学雑誌 2020; 43(6): 235-44.

論文報告2019

1. A Successful Case of Percutaneous Left Ventricular Assist Device “Impella” to Post-Myocardial Infarction

Ventricular Septal Perforation in Japan.

Mitsuru Iida*, Masateru Uchiyama, Tomoki Shimokawa.

Artificial Organs, 2019;43:806-7.

2. Systemic silencing of Phd2 causes reversible immune regulatory dysfunction.

Atsushi Yamamoto, Joanna Hester, Philip S. Macklin, Kento Kawai, Masateru Uchiyama, Daniel Biggs, Tammie

Bishop, Katherine Bull, Xiaotong Cheng, Eleanor Cawthorne, Mathew L. Coleman, Tanya L. Crockford,

Ben Davies, Lukas E. Dow, Rob Goldin, Kamil Kranc, Hiromi Kudo, Hannah Lawson, James McAuliffe,

Kate Milward, Cheryl L. Scudamore, Elizabeth Soilleux, Fadi Issa, Peter J. Ratcliffe, Chris W. Pugh*.

J Clin Invest. 2019; 129: 3640-3656.

3. The Early Outcome of Aortic Valve Replacement Surgery for Dialysis Patients.

Mitsuru Iida*, Kenji Nishimura, Kaori Kono, Ken Chen, Tsukasa Ikeda, Hiroo Ota, Masateru Uchiyama,

Naomi Ozawa, Tomohiro Imazuru, Tomoki Shimokawa.

Journal of Cardiol Ther. 2019; 6: 793-7.

論文報告2018

1. Rikkunshito (TJ-43) Improved Reduction of Food Intake in Murine Cardiac Transplant.

Yin E, Uchiyama M*, Niimi M.

Transplantation Proceedings. 2018;50:283-92.

2. Regulatory T cells for tolerance.

Kento Kawai, Masateru Uchiyama, Joanna Hester, Kathryn Wood, Fadi Issa.

Human Immunology. 2018;79:294-303.

3. More hippocampal weight and cells in cardiac allograft transplanted mice.

Enzhi Yin, Masateru Uchiyama*, Xiangyuan Jin, Kento Kawai, Masaki Takao, and Masanori Niimi

Transplantation Proceedings, 2018;50:2798-803.

4. Administration of Thrombomodulin (CD141) could improve cardiac allograft survival in mice.

Enzhi Yin, Shigefumi Matsuyamaeq, Masateru Uchiyama*, Michitaka Kono, Masanori Niimi

Transplantation Proceedings, 2018;50:2794-7.

5. Seven Japanese Herbals Prolonged Cardiac Allograft Survival.

Enzhi Yin, Xiangyuan Jin, Masateru Uchiyama*, Qi Zhang, Takako Yanagisawa, Akira Inoue, Yu Guo,

Masanori Hara, Shigefumi Matsuyama, Tomohiro Imazuru, Masafumi Kawamura, Masanori Niimi

Transplantation Proceedings, 2018;50:2789-93.

6. Graft protective effect and induction of CD4+Foxp3+ cell by Thrombomodulin on allograft arteriosclerosis

in mice.

Enzhi Yin, Shigefumi Matsuyama, Masateru Uchiyama*, Kento Kawai, Masanori Niimi

Journal of Cardiothoracic Surgery, 2018;13:48

7. Graft protective effect of HMG-CoA reductase inhibitor Pravastatin in murine cardiac allograft transplantation.

Enzhi Yin, Masanori Hara, Masateru Uchiyama*, Masanori Niimi.

Transplantation Proceedings, 2018;50:2804-6.

8. Surgical treatment of a huge hepatic artery aneurysm without revascularization - Case report.

Tomohiro Imazuru*, Masateru Uchiyama, Shigefumi Matsuyama, Mitsuru Iida, Tomoki Shimokawa.

International Journal of Surgery Case Reports, 2018;51:95-8.

論文報告2017

1. Yogurt Feeding Induced the Prolongation of Fully MHC-mismatched Murine Cardiac Graft Survival by induction

of CD4+Foxp3+ cells.

Masateru Uchiyama*, Enzhi Yin, Takako Yanagisawa, Xiangyuan Jin, Masanori Hara, Shigefumi Matsuyama,

Tomohiro Imazuru, Koichiro Uchida, Masafumi Kawamura, Masanori Niimi.

Transplantation Proceedings, 2017;49:1477-82.

論文報告2015

1. Treadmill Exercise Induces Murine Cardiac Allograft Survival and Generates Regulatory T cell.

Masateru Uchiyama, Xiangyuan Jin, Enzhi Yin, Tomoki Shimokawa, Masanori Niimi

Transplant International 2015;28:352-62.

2. Food Restriction Prolongs Murine Cardiac Grafts.

Uchiyama M*, Yin E, Jin X, Niimi M

Transplantation Proceedings, 2015;47:2528-32.

3. Induction of Regulatory T Cells and Prolongation of Fully Allogeneic Cardiac Grafts by Herbal Medicine,

Shohangekabukuryo-to.

Enzhi Yin, Masateru Uchiyama*, Xiangyuan Jin, Masanori Niimi

Alternative & Integrative Medicine, 2015;4:4.

論文報告2014

1. An Agonistic Anti-BTLA mAb (3C10) Induced Generation of IL-10 Dependent Regulatory CD4+ T Cells and

Prolongation of Murine Cardiac Allograft.

Masateru Uchiyama, Xiangyuan Jin, Hironori Matsuda, Hisashi Bashuda, Tomohiro Imazuru, Tomoki Shimokawa,

Hideo Yagita, Masanori Niimi

Transplantation, 2014;97:301-9.

2. Combination of Paeoniae Radix and Cnidii rhizome Prolonged Survival of Fully Mismatched Cardiac Allografts

and Generated Regulatory Cells in Mice

Xiangyuan Jin, Lei Yu, Masateru Uchiyama, Enzhi Yin, Tadanori Harada, Ken Otsuka, Shigefumi Matsuyama,

Tomohiro Imazuru, Tomoki Shimokawa, Masanori Niimi

Evidence-Based Complementary and Alternative Medicine, 2014;2014:841408.

3. Effect of 34 Kinds of Traditional Japanese Herbal Medicines on Prolongation of Cardiac Allograft Survival.

Xiangyuan Jin, Masateru Uchiyama, Tadanori Harada, Ken Otsuka, Qi Zhang, Tomoki Shimokawa,

Masanori Niimi

Transplantation Proceedings, 2014;46:1175-9.

4. Fox smell abrogates the effect of herbal odor to prolong mouse cardiac allograft survival

Xiangyuan Jin, Masateru Uchiyama, Qi Zhang, Masanori Niimi

Journal of Cardiothoracic Surgery, 2014;9:82

論文報告2013

1. Effects of Japanese herbal medicine Sairei-to on murine experimental autoimmune uveitis

Toshikatsu Kaburaki, Qi Zhang, Xiangyuan Jin, Masateru Uchiyama, Yujiro Fujino, Hisae Nakahara,

Mitsuko Takamoto, Kazuyoshi Otomo, Masanori Niimi

Graefes Arch Clin Exp Ophthalmol. 2013;251:2733-9.

論文報告2012

1. Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained

generation of regulatory CD4+CD25+ cells

Masateru Uchiyama, Xiangyuan Jin, Qi Zhang, Toshihito Hirai, Atsushi Amano, Hisashi Bashuda, Masanori Niimi

Journal of Cardiothoracic Surgery, 2012;7:26

2. Danazol Induces Prolonged Survival of Fully Allogeneic Cardiac Grafts and Maintains the Generation of

Regulatory CD4+ Cells in Mice.

Masateru Uchiyama, Xiangyuan Jin, Qi Zhang, Toshihito Hirai, Hisashi Bashuda, Toshiaki Watanabe,

Atsushi Amano, Masanori Niimi

Transplant International, 2012;25:357-65.

3. Induction of Regulatory CD4 Cells and Prolongation of Survival of Fully Allogeneic Murine Cardiac Grafts

by Danazol.

Masateru Uchiyama, Xiangyuan Jin, Qi Zhang, Atsushi Amano, Toshiaki Watanabe, Masanori Niimi

Transplantation Proceedings, 2012;44:1067–9.

4. Music Exposure Induced Prolongation of Cardiac Allograft Survival and Generated Regulatory CD4 Cells in Mice.

Masateru Uchiyama, Xiangyuan Jin, Qi Zhang, Atsushi Amano, Toshiaki Watanabe, Masanori Niimi

Transplantation Proceedings, 2012, 44, 1076–9.

5. The Smell of Tokishakuyaku-san (TJ-23) Induces Generation of Regulatory T Cells and Prolongation of Survival

of Fully Allogeneic Cardiac Grafts in Mice.

Xiangyuan Jin, Masateru Uchiyama, Qi Zhang, Toshiaki Watanabe, Masanori Niimi

Transplantation Proceedings, 2012, 44, 1070–2.

6. Artemisiae capillaris herba Induces Prolonged Survival of Fully Cardiac Allografts and Generates Regulatory Cells

in Mice.

Xiangyuan Jin, Masateru Uchiyama, Qi Zhang, Toshiaki Watanabe, Masanori Niimi

Transplantation Proceedings, 2012, 44, 1073–5.

7. Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched

Cardiac Allografts and Generated Regulatory Cells in Mice

Xiangyuan Jin, Masateru Uchiyama, Qi Zhang, Toshihito Hirai, Masanori Niimi

Evid Based Complement Alternat Med. 2012;2012:689810.

論文報告2011

1. Induction of regulatory T cells by administration of Tokishakuyaku-san in mice.

Qi Zhang, Masateru Uchiyama, Xiangyuan Jin, Daiki Iwami, Nozomu Shirasugi, Toshiaki Watanabe,

Masanori Niimi

Surgery. 2011 Nov; 150(5): 923-33.

論文報告2010

1. Impact of sairei-to and its individual constituents on cardiac allograft survival.

Qi Zhang, Xiangyuan Jin, Masateru Uchiyama, Shuji Yakubo, Masanori Niimi

The Journal of Heart and Lung Transplantation, 2010; 29: 818-20.

2. Prolongation of renal allograft survival by anergic cells.

Hisashi Bashuda, Akira Shimizu, Masateru Uchiyama, Ko Okumura.

Clin Transplant, 2010: 24 (Suppl. 22): 6-10.

住所

〒173-8605 東京都板橋区加賀2-11-1

板橋キャンパス 大学棟本館 8階 805 外科学講座

2-11-1, Kaga, Itabashi-ku, Tokyo, Japan

電話番号

+81-3-3964-1211　Extension number: 48322

Mail

mautiya@med.teikyo-u.ac.jp